Friday, November 8, 2013

UNH, UC Davis launch network to study environmental microbes

UNH, UC Davis launch network to study environmental microbes


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7-Nov-2013



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Contact: Beth Potier
beth.potier@unh.edu
603-862-1566
University of New Hampshire






DURHAM, N.H. A grant to the University of New Hampshire and the University of California, Davis, will help biologists identify an abundant yet largely unknown category of organisms, leading to better understanding of the vital environmental functions they play.


The National Science Foundation awarded the two universities $500,000 to develop a Research Coordination Network on eukaryotic biodiversity. The work will apply new genome sequencing technology to study and classify microscopic eukaryote species like nematodes, fungi, and single-celled animals.


These small yet complex organisms are invisible to the eye but abundant in marine and terrestrial environments from sandy beaches to garden plots. "If you're making a sandcastle, there are thousands and thousands of these creatures in a handful of sand. They provide key ecosystem services," says co-principal investigator W. Kelley Thomas, Hubbard Professor in Genomics and director of UNH's Hubbard Center for Genome Studies. They process waste, cycle nutrients, and even "eat" spilled oil, he says.


"I call them the 'dark matter' of biology," says Holly Bik, a postdoctoral researcher at UC Davis and co-principal investigator on the project. "They are in every single environment, but no one looks at them." Bik worked with Thomas as a postdoctoral researcher at UNH.


The traditional taxonomic approach to biodiversity involves looking at an organism and describing the features legs, wings, teeth, leaves that make it similar to or distinct from other organisms. Because taxonomy is far easier and more efficient to apply to cats and cows and pine trees than to microscopic organisms like nematodes, knowledge of the Earth's biodiversity shows a distinct bias toward larger species.



Now, new high-throughput DNA sequencing technology makes it possible to identify and classify these organisms much more quickly and comprehensively, describing each species with a short "barcode" of several hundred nucleotides.


The goal of this new network is to bring together researchers from different fields: taxonomists expert in identifying organisms; ecologists who study these ecosystems; genome scientists and computational biologists who can figure out how to analyze sequence data from these relatively complex animals.


The team aims to organize an annual "catalysis" meeting to bring researchers together, and they will also sponsor symposia at other scientific meetings. The program will bring scientists from around the world to UNH to collaborate toward better understand global patterns of biodiversity and ecosystem function. In addition, it will support an expanded relationship with two biodiversity experts (Eyualem Abebe at Elizabeth City State University and Jyotsna Sharma-Srinivasan at The University of Texas, San Antonio). These partners serve significant populations of undergraduates from underrepresented groups and expand the potential diversity of scientists that will ultimately address long standing questions in biodiversity.


The network will also develop undergraduate training programs on taxonomy and genomics, based at UNH. Activities like "bioinformatics bootcamps" will enhance students' research skills through interdisciplinary training.


"If we want the field to move forward we need to train the next generation of scientists," Bik says.

###




The University of New Hampshire, founded in 1866, is a world-class public research university with the feel of a New England liberal arts college. A land, sea, and space-grant university, UNH is the state's flagship public institution, enrolling 12,300 undergraduate and 2,200 graduate students.


Photographs available to download: http://unh.edu/news/releases/2012/sept/kelleythomas.jpg

Caption: W. Kelley Thomas, Hubbard Professor in Genomics and director of UNH's Hubbard Center for Genome Studies.

Credit: Mike Ross, UNH Photographic Services


http://www.unh.edu/news/releases/2013/11/images/eukaryote-8347.jpg

Caption: A marine nematode.

Credit: James Baldwin and Manuel Mundo, UCR




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UNH, UC Davis launch network to study environmental microbes


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

7-Nov-2013



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]


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Contact: Beth Potier
beth.potier@unh.edu
603-862-1566
University of New Hampshire






DURHAM, N.H. A grant to the University of New Hampshire and the University of California, Davis, will help biologists identify an abundant yet largely unknown category of organisms, leading to better understanding of the vital environmental functions they play.


The National Science Foundation awarded the two universities $500,000 to develop a Research Coordination Network on eukaryotic biodiversity. The work will apply new genome sequencing technology to study and classify microscopic eukaryote species like nematodes, fungi, and single-celled animals.


These small yet complex organisms are invisible to the eye but abundant in marine and terrestrial environments from sandy beaches to garden plots. "If you're making a sandcastle, there are thousands and thousands of these creatures in a handful of sand. They provide key ecosystem services," says co-principal investigator W. Kelley Thomas, Hubbard Professor in Genomics and director of UNH's Hubbard Center for Genome Studies. They process waste, cycle nutrients, and even "eat" spilled oil, he says.


"I call them the 'dark matter' of biology," says Holly Bik, a postdoctoral researcher at UC Davis and co-principal investigator on the project. "They are in every single environment, but no one looks at them." Bik worked with Thomas as a postdoctoral researcher at UNH.


The traditional taxonomic approach to biodiversity involves looking at an organism and describing the features legs, wings, teeth, leaves that make it similar to or distinct from other organisms. Because taxonomy is far easier and more efficient to apply to cats and cows and pine trees than to microscopic organisms like nematodes, knowledge of the Earth's biodiversity shows a distinct bias toward larger species.



Now, new high-throughput DNA sequencing technology makes it possible to identify and classify these organisms much more quickly and comprehensively, describing each species with a short "barcode" of several hundred nucleotides.


The goal of this new network is to bring together researchers from different fields: taxonomists expert in identifying organisms; ecologists who study these ecosystems; genome scientists and computational biologists who can figure out how to analyze sequence data from these relatively complex animals.


The team aims to organize an annual "catalysis" meeting to bring researchers together, and they will also sponsor symposia at other scientific meetings. The program will bring scientists from around the world to UNH to collaborate toward better understand global patterns of biodiversity and ecosystem function. In addition, it will support an expanded relationship with two biodiversity experts (Eyualem Abebe at Elizabeth City State University and Jyotsna Sharma-Srinivasan at The University of Texas, San Antonio). These partners serve significant populations of undergraduates from underrepresented groups and expand the potential diversity of scientists that will ultimately address long standing questions in biodiversity.


The network will also develop undergraduate training programs on taxonomy and genomics, based at UNH. Activities like "bioinformatics bootcamps" will enhance students' research skills through interdisciplinary training.


"If we want the field to move forward we need to train the next generation of scientists," Bik says.

###




The University of New Hampshire, founded in 1866, is a world-class public research university with the feel of a New England liberal arts college. A land, sea, and space-grant university, UNH is the state's flagship public institution, enrolling 12,300 undergraduate and 2,200 graduate students.


Photographs available to download: http://unh.edu/news/releases/2012/sept/kelleythomas.jpg

Caption: W. Kelley Thomas, Hubbard Professor in Genomics and director of UNH's Hubbard Center for Genome Studies.

Credit: Mike Ross, UNH Photographic Services


http://www.unh.edu/news/releases/2013/11/images/eukaryote-8347.jpg

Caption: A marine nematode.

Credit: James Baldwin and Manuel Mundo, UCR




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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-11/uonh-uud110713.php
Category: steve bartman   parenthood   nfl standings   nfl schedule   nbc sports  

Report: CIA pays AT&T for international call data


AT&T supplies information on international calls that travel over its network, including ones that start or end in the U.S., under a voluntary contract with the U.S. Central Intelligence Agency, The New York Times reported Thursday.


The CIA pays the carrier more than $10 million annually for the data, including the date, duration, and numbers involved in a call, the Times said, citing unnamed government officials. The calls include ones that are made by customers of other carriers but travel partly on AT&T's network. For calls with a U.S. participant, AT&T doesn't tell the CIA the identity of the U.S. caller and masks several digits of the domestic number, the report said.


[ Learn how to protect your systems with Roger Grimes' Security Adviser blog and Security Central newsletter, both from InfoWorld. ]


The CIA isn't allowed to conduct domestic spying. However, the agency can hand over the masked numbers to the Federal Bureau of Investigation, which can subpoena AT&T for the uncensored data, the Times said. The FBI, in turn, sometimes shares information with the CIA about the U.S. participant in a call.


The latest report is likely to heighten concerns about the U.S. government's surveillance of voice and data communications around the world. Disclosures made by former National Security Agency contractor Edward Snowden starting earlier this year have helped to spark calls for reform of surveillance practices and rankled several U.S. allies.


In an emailed statement, the CIA said it doesn't comment on alleged intelligence sources or methods.


"The CIA protects the nation and upholds the privacy rights of Americans by ensuring that its intelligence collection activities are focused on acquiring foreign intelligence and counterintelligence in accordance with U.S. laws," said Dean Boyd, director of the CIA Office of Public Affairs. The agency is subject to oversight from multiple entities, he said.


AT&T does not comment on questions concerning national security, spokesman Mark Siegel said in a statement emailed to IDG News Service.


"In all cases, whenever any governmental entity anywhere seeks information from us, we ensure that the request and our response are completely lawful and proper," Siegel wrote. "We ensure that we maintain customer information in compliance with the laws of the United States and other countries where information may be maintained. Like all telecom providers, we routinely charge governments for producing the information provided."


Stephen Lawson covers mobile, storage and networking technologies for The IDG News Service. Follow Stephen on Twitter at @sdlawsonmedia. Stephen's e-mail address is stephen_lawson@idg.com


Source: http://www.infoworld.com/d/security/report-cia-pays-att-international-call-data-230441?source=rss_mobile_technology
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CMA Awards, fellow stars salute George Strait


NASHVILLE, Tenn. (AP) — The entertainer of the year trophy at the Country Music Association Awards is one of the most coveted honors in the genre, but sometimes it's OK to lose — like, say, when George Strait is a nominee.

Strait won his third entertainer of the year award and his first since 1990 o9n Wednesday night against country music's current hit makers, and no one seemed disappointed. Blake Shelton — one of five performers with a leading two victories — was excited to lose to the 61-year-old whose popularity defies his age.

"That's how it needs to be because he's not just entertainer of the year, he's entertainer of the last three decades, I guess, or four decades," Shelton said. "I don't know who's keeping score. I mean, it's George Strait. He's King George. I couldn't be happier with how this turned out."

Shelton was one of five top winners with two trophies apiece, along with Florida Georgia Line and the trio of Taylor Swift, Tim McGraw and Keith Urban, who won music video and music event of the year for their "Highway Don't Care" collaboration.

Like Strait, Swift also was going for her third entertainer of the year, which would have been a CMA record for a woman. Like Shelton, she couldn't have cared less when she lost, instead hugging Faith Hill as they cried tears of joy for Strait. She noted they've both opened for Strait in their careers and she recounted a story about how Strait and his wife Norma dropped in to one of her first headlining concerts when she was a teenager just to wish her luck.

The crowd gave Strait a standing ovation as he made his way to the stage, and stayed standing throughout his speech. It wasn't just a special night for those in the arena. It was also the show's top trending moment on Facebook.

His retirement from the road has gained lots of attention, but Strait isn't a relic. He recently earned his record 60th No. 1 and signed a five-album deal with Universal Music Nashville.

Backstage, he shared with reporters how it has felt as he circles the country on his The Cowboy Rides Away tour, his last.

"When I first started out this year, the first few shows, I about lost it every night, you know, leaving the stage ... thinking, 'This might be the last time I ever play on this stage again,'" Strait said.

Strait's victory capped a show that was simultaneously focused on the past, present and future.

Shelton, his wife Miranda Lambert and Swift all continued their winning ways. Shelton took album of the year for "Based on a True Story ...," and won his fourth male vocalist of the year. Voters supplied some symmetry when they named Lambert female vocalist of the year, also for the fourth time, tying her with friend Reba McEntire.

It was the third straight year in which Lambert or Shelton were among the top winners, and capped a year in which they were dogged by tabloid stories about their relationship. Lambert said she wasn't sure why the CMA's 6,000 voters love the couple so much.

"You know, pillow talk, literally, we're like, 'Well, our year was last year,'" Lambert said. "It was great, a great run while we had it. We'll drink tonight and celebrate all of our friends winning, because literally all of my friends won awards tonight."

Swift, who performed a somber, acoustic version of her hit "Red" with Vince Gill, Alison Krauss and Sam Bush, won her eighth and ninth CMA trophies before being honored with the association's Pinnacle Award, given to an artist who has taken country to a worldwide audience.

The CMA brought a star-studded welcoming group on stage for Swift that included Strait, Rascal Flatts, McGraw and Hill, Urban and Brad Paisley — all of whom gave Swift a chance to open for them on the road a teenager. A video salute followed with appearances by Justin Timberlake, Julia Roberts, Carly Simon, Ethel Kennedy and Mick Jagger — whose appearance made Swift shout.

"You've made me feel so special right now, thank you," Swift said.

Voters also cast an eye to the future, handing trophies to young stars Florida Georgia Line and Kacey Musgraves, who was a top nominee with Swift.

Florida Georgia Line's Tyler Hubbard and Brian Kelley scored single and vocal duo of the year. Their quick wins early in the show was more proof the so-called bro country movement is the sound of the moment in mainstream country. Florida Georgia Line kicked off the show performing a fist-pumping medley with Luke Bryan, and quickly returned to the stage to take the trophy for single of the year for their "Cruise" remix featuring Nelly. They also played the new song "Round Here."

"It's been a constant thing all year — we've been trying to wrap our minds around what's going on," Hubbard said backstage of the band's platinum success. "It's been a dream come true for us and a huge blessing for us and something we could have never imagined."

Musgraves won the new artist trophy, besting a field that included Florida Georgia Line.

"It's amazing what 52 weeks can do to a person," Musgraves said backstage. "... Last year I had really crappy seats. You know, I was just sitting back with my roommate just as a fan. And here I am holding this thing."

Lee Brice's "I'd Drive Your Truck," about a fallen soldier whose father still drives his truck, won song of the year, and Little Big Town took its second straight vocal group of the year.

Collaboration was the theme of the night as Strait and Alan Jackson joined together to salute the late George Jones with a rendition of "She Stopped Loving Him Today." Hunter Hayes and Jason Mraz took a tour of the Bridgestone Arena while performing "Everybody's Got Somebody But Me." And in one of the night's most anticipated moments, Kenny Rogers received the CMA's Willie Nelson lifetime achievement award.

___

Online:

http://www.cmaawards.com

___

Follow AP Entertainment for updates from the show: http://twitter.com/APEntertainment. Follow AP Music Writer Chris Talbott: http://twitter.com/Chris_Talbott .

Source: http://news.yahoo.com/cma-awards-fellow-stars-salute-george-strait-083510678.html
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Thursday, November 7, 2013

Senate OKs gay rights bill banning discrimination

There were smiles all around as Democrats gathered after the Senate cut off debate to move toward a historic vote on legislation outlawing workplace discrimination against gay, bisexual and transgender Americans, demonstrating the nation's quickly evolving attitude toward gay rights nearly two decades after Congress rejected same-sex marriage, on Capitol Hill in Washington, Thursday, Nov. 7, 2013. From left are, Senate Majority Leader Harry Reid, D-Nev., Sen. Tammy Baldwin, D-Wis., Sen. Tom Harkin, D-Iowa, Sen. Jeff Merkley, D-Ore., Sen. Patty Murray, D-Wash., Sen. Charles Schumer, D-N.Y. The enthusiasm of the bill's supporters was tempered by the reality that the Republican-led House, where conservatives have a firm grip on the agenda, is unlikely to even vote on it. (AP Photo/J. Scott Applewhite)







There were smiles all around as Democrats gathered after the Senate cut off debate to move toward a historic vote on legislation outlawing workplace discrimination against gay, bisexual and transgender Americans, demonstrating the nation's quickly evolving attitude toward gay rights nearly two decades after Congress rejected same-sex marriage, on Capitol Hill in Washington, Thursday, Nov. 7, 2013. From left are, Senate Majority Leader Harry Reid, D-Nev., Sen. Tammy Baldwin, D-Wis., Sen. Tom Harkin, D-Iowa, Sen. Jeff Merkley, D-Ore., Sen. Patty Murray, D-Wash., Sen. Charles Schumer, D-N.Y. The enthusiasm of the bill's supporters was tempered by the reality that the Republican-led House, where conservatives have a firm grip on the agenda, is unlikely to even vote on it. (AP Photo/J. Scott Applewhite)







Sen. Tammy Baldwin, D-Wis., center, the Senate’s first openly gay member, is surrounded by fellow Democrats just before a historic vote on legislation outlawing workplace discrimination against gay, bisexual and transgender Americans, Thursday, Nov. 7, 2013, on Capitol Hill in Washington. From left are, Senate Majority Leader Harry Reid of Nev., Senate Majority Whip Richard Durbin of Ill., Sen. Tom Harkin, D-Iowa, Baldwin, Sen. Jeff Merkley, D-Ore., Sen. Patty Murray, D-Wash., and Sen. Charles Schumer, D-N.Y. Senate passage of the bill is a major victory for gay rights advocates in a momentous year that included the Supreme Court’s affirmation of gay marriage and the granting of federal benefits to legally married same-sex couples. The enthusiasm of the bill's supporters was tempered by the reality that the Republican-led House, where conservatives have a firm grip on the agenda, is unlikely to even vote on it. (AP Photo/J. Scott Applewhite)







Senate Majority Leader Harry Reid of Nev. leads a news conference on Capitol Hill in Washington, Thursday, Nov. 7, 2013, as Democrats gathered after the Senate cut off debate to move toward a historic vote on legislation to outlaw workplace discrimination against gay, bisexual and transgender Americans, demonstrating the nation's quickly evolving attitude toward gay rights nearly two decades after Congress rejected same-sex marriage. From left are, Senate Majority Whip Richard Durbin of Ill., Reid, Sen. Tom Harkin, D-Iowa, Sen. Patty Murray, D-Wash., Sen. Charles Schumer, D-N.Y., and Sen. Jeff Merkley, D-Ore. (AP Photo/J. Scott Applewhite)







(AP) — Reflecting Americans' increasing acceptance of gays, the Senate on Thursday approved legislation that would bar workplace discrimination based on sexual orientation and gender identity.

Gay rights advocates hailed the bipartisan, 64-32 vote as a historic step although it could prove short-lived. A foe of the bill, Speaker John Boehner, R-Ohio, has signaled that the Republican-led House is unlikely to even vote. Senate proponents were looking for a way around that obstacle.

Seventeen years after a similar anti-discrimination measure failed by one vote, 54 members of the Senate Democratic majority and 10 Republicans voted for the Employment Non-Discrimination Act. It is the first major gay rights bill since Congress repealed the ban on gays serving openly in the military three years ago.

"All Americans deserve a fair opportunity to pursue the American dream," said Sen. Susan Collins, R-Maine, a chief sponsor of the bill.

Proponents cast the effort as Congress following the lead of business and localities as some 90 percent of Fortune 500 companies and 22 states have outlawed employment discrimination against gay, bisexual and transgender Americans.

Supporters described it as the final step in a long congressional fight against discrimination, coming nearly 50 years after enactment of the Civil Rights Act and 23 years after the Americans with Disabilities Act.

"Now we've finished the trilogy," said Sen. Tom Harkin, D-Iowa, a chief sponsor of the disabilities law, at a Capitol Hill news conference.

Two Republican senators who voted against anti-discrimination legislation in 1996, Arizona's John McCain, the presidential nominee in 2008, and Orrin Hatch of Utah, backed the measure this time. Alaska Republican Sen. Lisa Murkowski voted in favor; her father, Frank, opposed a similar bill nearly two decades ago, underscoring the generational shift.

"Let the bells of freedom ring," said Sen. Jeff Merkley, D-Ore., who took the lead on the legislation from the late Sen. Ted Kennedy, D-Mass.

Senate passage came in a momentous year for gay rights advocates. The Supreme Court in June granted federal benefits to legally married same-sex couples, though it avoided a sweeping ruling that would have paved the way for same-sex unions nationwide. Illinois is on the verge of becoming the 15th state to legalize gay marriage along with the District of Columbia.

A Pew Research survey in June found that more Americans said homosexuality should be accepted rather than discouraged by society by a margin of 60 percent to 31 percent. Opinions were more evenly divided 10 years ago.

In the House, Boehner has maintained his longstanding opposition despite pleas from national Republicans for the GOP to broaden its appeal to a fast-changing demographic. Boehner argues that the bill is unnecessary and would touch off costly, meritless lawsuits for businesses.

President Barack Obama and Democrats used the progressive legislation piling up in the House as a cudgel on the GOP, with the gay rights bill likely to join the stalled measure to overhaul the immigration system.

Sen. Chuck Schumer, D-N.Y., said if the House fails to act, "they'll be sending their party straight to oblivion."

Sen. Dick Durbin of Illinois reminded Boehner of the history of his party in the 1880s over the issue of slavery and Abraham Lincoln's life work.

"Keep that proud Republican tradition alive," Durbin said.

Obama, in a statement, said "one party in one house of Congress should not stand in the way of millions of Americans who want to go to work each day and simply be judged by the job they do."

Gay rights advocates reminded Obama that he could act unilaterally and issue an executive order barring anti-gay workplace discrimination by federal contractors. Chad Griffin, the president of the Human Rights Campaign, said Obama is empowered to act and called on him to sign the executive order.

One possible option exists for proponents, adding the gay rights bill to the annual defense policy measure that the Senate will consider later this month and force the House to reject the popular legislation.

Through three days of Senate debate, opponents of the legislation remained mute, with no lawmaker speaking out. That changed on Thursday, as Republican Sen. Dan Coats of Indiana said the legislation would force employers to violate their religious beliefs.

"There's two types of discrimination here we're dealing with, and one of those goes to the very fundamental right granted to every American through our Constitution, a cherished value of freedom of expression and religion," Coats said.

Current federal law prohibits discrimination on the basis of sex, race and national origin. But it doesn't stop an employer from firing or refusing to hire workers because they are gay, lesbian, bisexual or transgender.

The bill would bar employers with 15 or more workers from using a person's sexual orientation or gender identity as the basis for making employment decisions, including hiring, firing, compensation or promotion. It would exempt religious institutions and the military.

The Senate approved an amendment from Republican Sens. Rob Portman of Ohio and Kelly Ayotte of New Hampshire that would prevent federal, state and local governments from retaliating against religious groups that are exempt from the law.

The Senate rejected an amendment sponsored by Republican Sen. Pat Toomey of Pennsylvania that would have expanded the number of groups that are covered under the religious exemption.

Portman, Ayotte and Toomey voted for the legislation.

The first openly gay senator, Democrat Tammy Baldwin of Wisconsin, called the vote a "tremendous milestone" that she will always remember throughout her time in the Senate.

Sens. Tom Coburn, R-Okla., John Barrasso, R-Wyo., and Jeff Sessions, R-Ala., did not vote. Sen. Bob Casey, D-Pa., a supporter of the bill, said his wife underwent heart surgery this week and he was unable to make the vote.

____

Follow Donna Cassata on Twitter at http://twitter.com/DonnaCassataAP

Associated PressSource: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-11-07-US-Gay-Rights-Senate/id-eb3e8ec9888e44298a277b75423ca0e6
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Dan Henderson, Vitor Belfort granted TRT exemptions for UFN 32


UFC Fight Night 32 will feature the first MMA fight between athletes on testosterone-replacement therapy.


Vitor Belfort and Dan Henderson, who meet on Nov. 9 in Goiania, Brazil, were granted the TRT exemptions for their light heavyweight contest for the main event. Brazilian MMA Athletic Commission’s (CABMMA) medical director, Dr. Marcio Tannure, told MMAFighting.com their exams were approved by the commission.


MMAJunkie first reported the news.


"They were already on treatment," Dr. Tannure told MMAFighting.com, "and CABMMA approved their exams to continue the treatment for this fight."


According to Dr. Tannure, Belfort and Henderson are the only fighters on the card who required for an exemption to use the testosterone therapy.


Belfort enters the cage after consecutive knockout victories over Michael Bisping and Luke Rockhold in Brazil, while Henderson looks to get back to the win column following back-to-back split-decision losses to Rashad Evans and Lyoto Machida.


Source: http://www.mmafighting.com/2013/11/7/5078064/dan-henderson-vitor-belfort-granted-trt-exemptions-for-ufn-32
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Levi Johnston Takes Bristol Palin to Court for Joint Custody of Tripp

Their relationship may be long gone, but Bristol Palin and Levi Johnston are still at odds over their son, Tripp.


Though the former vice presidential candidate's daughter has had full custody of the little boy, her former fiancée has filed a petition asking for equal custody of the child.


In the documents, the 23-year-old asks for as much time with his son as the 4-year-old's mother. However, Bristol responded claiming that he owes $66,000 in child support, hinting that the request is financially motivated.


Back in 2008, the pair experienced happy times, announcing both their engagement and her pregnancy during the presidential election. Young love didn't last, though, and the two broke off their engagement in December 2008, reunited, then called it quits in August 2010. Since then, Levi married Sunny Oglesby.


Source: http://celebrity-gossip.net/bristol-palin/levi-johnston-takes-bristol-palin-court-joint-custody-tripp-957450
Category: miss america   Arsenio Hall  

Chicago Cubs hire Rick Renteria as new manager

FILE - In this Sept. 23, 2013, file photo, San Diego Padres bench coach Rick Renteria prepares to pitch batting practice for the Padres' baseball game against the Arizona Diamondbacks in San Diego. The Chicago Cubs are set to hire Renteria as their manager, a person familiar with the situations said Wednesday, Nov. 6. (AP Photo/Lenny Ignelzi, File)







FILE - In this Sept. 23, 2013, file photo, San Diego Padres bench coach Rick Renteria prepares to pitch batting practice for the Padres' baseball game against the Arizona Diamondbacks in San Diego. The Chicago Cubs are set to hire Renteria as their manager, a person familiar with the situations said Wednesday, Nov. 6. (AP Photo/Lenny Ignelzi, File)







FILE - In this March 8, 2013, file photo, Mexico's manager Rick Renteria, left, smiles as he celebrates a win over the United States with Adrian Gonzalez (23) after a World Baseball Classic baseball game in Phoenix. The Chicago Cubs are set to hire Renteria as their manager, a person familiar with the situations said Wednesday, Nov. 6. (AP Photo/Ross D. Franklin, File)







(AP) — The Chicago Cubs hired Padres bench coach Rick Renteria as their new manager Thursday, bringing in a 51-year-old, first-year skipper they hope will develop their young talent and help establish the long-suffering franchise as a regular postseason contender.

Renteria was given a three-year contract, with club options for 2017 and 2018. Terms were not disclosed.

He has spent the last six seasons in San Diego, the last three as bench coach. Renteria has also coached in the Florida Marlins organization and in March managed Mexico in the World Baseball Classic. He replaces Dale Sveum, who was fired after two losing seasons.

The Cubs were 127-197 under Sveum and finished in last place in the National League Central Division for the first time in seven years.

The team had targeted Yankees manager Joe Girardi, a Peoria, Ill., native and Northwestern product who once played for the Cubs. But the former catcher signed a four-year contract worth up to $20 million to stay with New York through 2017.

Besides Renteria, the Cubs interviewed former Mariners and Indians manager Eric Wedge, Rays bench coach Dave Martinez, former Nationals and Indians manager Manny Acta, former Diamond-backs manager A.J. Hinch, and Brad Ausmus, who was hired by the Tigers on Sunday.

Now it's up to Renteria to help Cubs President Theo Epstein continue the overhaul of a franchise that has infamously not won the World Series since 1908.

The Cubs have dumped long-term contracts and traded anyone of value in an effort to stock the farm system ever since Epstein was hired, hoping the payoff will be the sort of championship success he enjoyed in the front office in Boston.

Among Renteria's tasks will be getting the most out of shortstop Starlin Castro and first baseman Anthony Rizzo, two young players who have long-term contracts. Both were underwhelming last season and pitcher Jeff Samardzija had an up-and-down season.

With prospects Javier Baez, Jorge Soler, Albert Almora and Kris Bryant in the pipeline, the Cubs made it clear they want to provide the right environment for their young players to develop.

Renteria has 30 years of professional baseball experience, none of it as a big-league manager. He was a minor league manager in the minors for eight years with the Padres and Marlins. That followed a 13-year playing career that included all or part of five seasons with the Pirates (1986), Mariners (1987-88) and Marlins (1993-94). The 1980 draft pick was a career .237 hitter with 20 doubles, four home runs and 41 RBI in 184 major league games.

Associated PressSource: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-11-07-BBN-Cubs-Renteria/id-292a6e5cfabb4ca49a5d9c1fae6a2634
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FDA Moves To Phase Out Remaining Trans Fats In Food Supply





Crisco was the original product made with partially hydrogenated soybean oil, which contains trans fats. Today, Crisco has only small amounts of the fats.



Tony Dejak/ASSOCIATED PRESS


Crisco was the original product made with partially hydrogenated soybean oil, which contains trans fats. Today, Crisco has only small amounts of the fats.


Tony Dejak/ASSOCIATED PRESS


If the Food and Drug Administration has its way, an era of food technology will soon end. The agency announced Thursday it is aiming to ban partially hydrogenated vegetable oils from all food products.


Margaret Hamburg, the FDA commissioner, said at a press conference that her agency has come to the preliminary conclusion that the oils "are not generally recognized as safe for use in food."



If the agency makes this decision final, it will mean a complete ban on this ingredient.


Health concerns about the trans fats in the oil have been mounting for years. The biggest concern? Trans fats raise the risk of heart disease. The Centers for Disease Control and Prevention estimates that an FDA ban on trans fats could prevent an additional 7,000 deaths from heart disease each year and up to 20,000 heart attacks each year.


But it took decades for health officials to arrive at that conclusion.


Partially hydrogenated oil came on the market about a century ago when food scientists figured out how to add hydrogen atoms to a molecule of oil. Typically, it's soybean oil.


Kantha Shelke, a scientist with the Institute of Food Technologists in Chicago, says this makes liquid oil more solid, and stable. Depending on how you add the hydrogen atoms, you can make the oil as solid as you like.




"So we could literally dial the needle to as solid as you wanted, and get the kind of results we were looking for," says Shelke.


These results include cookies or doughnuts that didn't leave a ring of oil behind on a paper towel and don't start tasting rancid after a few weeks.


Also, this oil doesn't have a strong taste of its own so you can use lots of it without ruining the flavor.


"It's really absolutely perfect, and it's also perfect for the American style of shopping: You buy boxes and boxes of crackers, put them in your pantry," says Shelke. "You open this box six months or eight months or a year later, and it would still taste and smell just as good as it was on the day you bought it!"


By the time the government came up with laws regulating food additives, people had been eating this form of oil for decades with no apparent problems.


David Schleifer, a researcher at a nonprofit group called Public Agenda, in New York, says most scientists in the 1980s actually thought this kind of oil was probably safer than lard or palm oil. Schleifer wrote a recent journal article on the history of trans fats.


McDonald's, Schleifer says, previously used beef tallow for frying. "People freaked out about beef tallow because it had saturated fat, and McDonald's responded to that public outcry by replacing beef tallow with trans fat," he says.


Everything changed in the mid-1990s. New studies showed that trans fats raised bad cholesterol and increased the risk of heart disease.


In fact, they were even worse than saturated fats. In 2006, after a campaign by public health advocates, the FDA required food companies to add trans fats to food labels.


Most companies responded by drastically cutting their use of partially hydrogenated oil. That had a big impact on consumption — Americans consumed around 1 gram per day in 2012, down from 4.6 grams per day in 2003.


But not every company has eliminated it from every product.


You can still find trans fats in microwavable popcorn, frozen pies and all kinds of mass-produced baked goods. Often, food companies use just a little bit. If there's less than half a gram of trans fats per serving they can list the amount of trans fats in their products as zero.


A complete ban on trans fats would be a big deal for food manufacturers, says Shelke. She says food companies can drop the trans fats, but their products won't be quite the same.


"They have to go back to re-educating consumers that cookies and consumers don't last forever," says Shelke.


The cookies will have a shorter life, but consumers' lives might be longer.


Source: http://www.npr.org/blogs/thesalt/2013/11/07/243730263/fda-moves-to-phase-out-remaining-trans-fats-in-food-supply?ft=1&f=1001
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Hope builds for a drug that might shut down a variety of cancers

Hope builds for a drug that might shut down a variety of cancers


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Weill Cornell Medical College



Cancer cells 'go to sleep' when crucial set of molecules is targeted




NEW YORK (November 7, 2013) -- The most frequently mutated gene across all types of cancers is a gene called p53. Unfortunately it has been difficult to directly target this gene with drugs. Now a multi-institutional research team, led by Dr. Lewis Cantley and investigators at Weill Cornell Medical College, has identified a family of enzymes they say is crucial for the growth of cancers that have genetic aberrations in p53. Targeting these enzymes with novel agents might prevent the growth of p53 mutant cancers, thereby benefiting a broad spectrum of cancer patients, including those with breast, ovarian, lung, colorectal and brain tumors.


In the Nov. 7 issue of Cell, investigators pinpoint two cellular enzymes -- Type 2 phosphatidylinositol-5-phosphate 4-kinases α and β (Type 2 PIP kinases) -- as essential for cancer growth when cells have lost p53, the powerful tumor-suppressor gene long dubbed the "guardian of the genome." More than half of all cancers lose this gene, allowing these cancers to grow at will.


The researchers discovered that the Type 2 PIP kinases are not critical for the growth of normal cells but become essential for cell growth when p53 is lost due to mutations or deletions. The scientists showed, in animal and lab studies of human cancer cells, that targeting these molecules effectively shuts down the growth of p53 mutant cancers.


Although the studies were conducted in human breast cancer cells, the researchers believe Type 2 PIP kinase inhibitors could block the growth of cancers with a mutated or missing p53 gene.


"The fact that one can delete the Type 2 PIP kinases in normal human cells or in mice with essentially no effect on cell survival suggests that inhibitors of these enzymes should have little toxicity," says Dr. Cantley, the study's senior author and director of the Cancer Center at Weill Cornell Medical College and NewYork-Presbyterian Hospital.


Dr. Cantley is already leading an effort to develop drugs to shut down these kinases. "Well-designed Type 2 PIP kinase inhibitors may turn the tide on p53 mutant cancer," he says.


A Crucial Link


Dr. Cantley is known for his discovery of the PI 3-kinase oncogene, and pioneering work in teasing apart how the gene contributes to cancer. PI 3-kinases (PI3K) have been linked to a wide variety of cellular functions, including cell growth and proliferation, and most cancers activate PI3K by one or more mechanisms. Dr. Cantley's discovery led to promising avenues for the development of personalized cancer therapies.


Activity of PI3K is in some cases linked to Type 2 PIP kinases, so in this study, Dr. Cantley sought to understand the function of these enzymes. Because the researchers knew that a subset of breast cancers over-express these molecules, investigators looked at their role in HER2-positive breast cancers, which typically are more aggressive tumors.


The researchers, including those from Harvard Medical School, Beth Israel Deaconess Medical Center and other institutions, discovered that the enzymes are silent in cells that have healthy p53. One critical role of p53 is to "rescue" cells that are producing excess reactive oxygen species (ROS), which are byproducts of cells that are growing too rapidly. The oxidative stress produced by ROS can damage cell structures, so p53 attempts to reduce ROS in affected cells. "If, however, ROS levels exceed the capacity of p53s to rescue it, then p53 takes on a second function, which is to kill the cell," Dr. Cantley says.


"That is why cancers often disable p53. If p53 is mutated or gone, then the cell keeps on growing at a very high rate," he says. "And then ROS begins to damage genes, making the cancer even more aggressive."


The Type 2 PIP kinases are the backup rescue system to p53. But they only reduce ROS enough to keep the cells from dying. (Too much ROS will also kill a cell.)


What this means is that cancer cells become "absolutely dependent on these kinases to be able to grow," Dr. Cantley says.


Taking Advantage of "Synthetic Lethality"


But there is a big and important hitch in this scenario, he adds. If the Type 2 PIP kinases are inhibited, and if p53 is deactivated, the cancer cell essentially "goes to sleep," he says. "It just stops dividing and growing. This is called synthetic lethality: You can get by without one gene or another, but if you lose both of them nothing can grow."


Shutting down these enzymes, as the researchers did in their experiments, puts cancer cells to sleep but has no effect on healthy cells. "A normal cell doesn't need Type 2 PIP kinases at all, so inhibitors of these enzymes should not be toxic to humans," Dr. Cantley says.


Because it is not possible to replace p53 proteins or the gene in cells that have lost it (many attempts have been made), deactivating Type 2 PIP kinases is the next-best thing, he adds. "This would likely be a very powerful advance in the treatment of many cancers."


###


This work was supported by NIH grant R01 GM041890 and by a Stand Up to Cancer Dream Team Translational Research Grant, a Program of the Entertainment Industry Foundation (SU2C-AACR-DT0209).


Co-authors include first author Dr. Brooke M. Emerling, Gary Bellinger and Rayman Choo-Wing from Weill Cornell Medical College; Dr. George Poulogiannis, Kazumi S. Tsukazawa, Hye-Seok Shim, and Dr. Gina M. DeNicola from Harvard Medical School; Dr. Gerburg M. Wulf, Dr. John M. Asara, Xin Yuan, and Dr. Andrea Bullock from Beth Israel Deaconess Medical School; Dr. Jonathan B. Hurov from Agios Pharmaceuticals; Dr. Eric L. Bell from the Massachusetts Institute of Technology; Dr. Katja A. Lamia from The Scripps Research Institute; Dr. Lucia E. Rameh from Boston University School of Medicine; Dr. Atsuo T. Sasaki from the University of Cincinnati College of Medicine; Dr. Jiaxi Song, Dr. Victoria Brown, and Dr. Sabina Signoretti from Dr. Dana-Farber Cancer Institute.


Weill Cornell Medical College

Weill Cornell Medical College, Cornell University's medical school located in New York City, is committed to excellence in research, teaching, patient care and the advancement of the art and science of medicine, locally, nationally and globally. Physicians and scientists of Weill Cornell Medical College are engaged in cutting-edge research from bench to bedside, aimed at unlocking mysteries of the human body in health and sickness and toward developing new treatments and prevention strategies. In its commitment to global health and education, Weill Cornell has a strong presence in places such as Qatar, Tanzania, Haiti, Brazil, Austria and Turkey. Through the historic Weill Cornell Medical College in Qatar, the Medical College is the first in the U.S. to offer its M.D. degree overseas. Weill Cornell is the birthplace of many medical advances including the development of the Pap test for cervical cancer, the synthesis of penicillin, the first successful embryo-biopsy pregnancy and birth in the U.S., the first clinical trial of gene therapy for Parkinson's disease, and most recently, the world's first successful use of deep brain stimulation to treat a minimally conscious brain-injured patient. Weill Cornell Medical College is affiliated with NewYork-Presbyterian Hospital, where its faculty provides comprehensive patient care at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. The Medical College is also affiliated with Houston Methodist. For more information, visit weill.cornell.edu.



Office of External Affairs

Weill Cornell Medical College

tel: 646.317.7401

email: pr@med.cornell.edu

Follow WCMC on Twitter and Facebook



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Hope builds for a drug that might shut down a variety of cancers


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Contact: Sarah Smith
sas2072@med.cornell.edu
646-317-7401
Weill Cornell Medical College



Cancer cells 'go to sleep' when crucial set of molecules is targeted




NEW YORK (November 7, 2013) -- The most frequently mutated gene across all types of cancers is a gene called p53. Unfortunately it has been difficult to directly target this gene with drugs. Now a multi-institutional research team, led by Dr. Lewis Cantley and investigators at Weill Cornell Medical College, has identified a family of enzymes they say is crucial for the growth of cancers that have genetic aberrations in p53. Targeting these enzymes with novel agents might prevent the growth of p53 mutant cancers, thereby benefiting a broad spectrum of cancer patients, including those with breast, ovarian, lung, colorectal and brain tumors.


In the Nov. 7 issue of Cell, investigators pinpoint two cellular enzymes -- Type 2 phosphatidylinositol-5-phosphate 4-kinases α and β (Type 2 PIP kinases) -- as essential for cancer growth when cells have lost p53, the powerful tumor-suppressor gene long dubbed the "guardian of the genome." More than half of all cancers lose this gene, allowing these cancers to grow at will.


The researchers discovered that the Type 2 PIP kinases are not critical for the growth of normal cells but become essential for cell growth when p53 is lost due to mutations or deletions. The scientists showed, in animal and lab studies of human cancer cells, that targeting these molecules effectively shuts down the growth of p53 mutant cancers.


Although the studies were conducted in human breast cancer cells, the researchers believe Type 2 PIP kinase inhibitors could block the growth of cancers with a mutated or missing p53 gene.


"The fact that one can delete the Type 2 PIP kinases in normal human cells or in mice with essentially no effect on cell survival suggests that inhibitors of these enzymes should have little toxicity," says Dr. Cantley, the study's senior author and director of the Cancer Center at Weill Cornell Medical College and NewYork-Presbyterian Hospital.


Dr. Cantley is already leading an effort to develop drugs to shut down these kinases. "Well-designed Type 2 PIP kinase inhibitors may turn the tide on p53 mutant cancer," he says.


A Crucial Link


Dr. Cantley is known for his discovery of the PI 3-kinase oncogene, and pioneering work in teasing apart how the gene contributes to cancer. PI 3-kinases (PI3K) have been linked to a wide variety of cellular functions, including cell growth and proliferation, and most cancers activate PI3K by one or more mechanisms. Dr. Cantley's discovery led to promising avenues for the development of personalized cancer therapies.


Activity of PI3K is in some cases linked to Type 2 PIP kinases, so in this study, Dr. Cantley sought to understand the function of these enzymes. Because the researchers knew that a subset of breast cancers over-express these molecules, investigators looked at their role in HER2-positive breast cancers, which typically are more aggressive tumors.


The researchers, including those from Harvard Medical School, Beth Israel Deaconess Medical Center and other institutions, discovered that the enzymes are silent in cells that have healthy p53. One critical role of p53 is to "rescue" cells that are producing excess reactive oxygen species (ROS), which are byproducts of cells that are growing too rapidly. The oxidative stress produced by ROS can damage cell structures, so p53 attempts to reduce ROS in affected cells. "If, however, ROS levels exceed the capacity of p53s to rescue it, then p53 takes on a second function, which is to kill the cell," Dr. Cantley says.


"That is why cancers often disable p53. If p53 is mutated or gone, then the cell keeps on growing at a very high rate," he says. "And then ROS begins to damage genes, making the cancer even more aggressive."


The Type 2 PIP kinases are the backup rescue system to p53. But they only reduce ROS enough to keep the cells from dying. (Too much ROS will also kill a cell.)


What this means is that cancer cells become "absolutely dependent on these kinases to be able to grow," Dr. Cantley says.


Taking Advantage of "Synthetic Lethality"


But there is a big and important hitch in this scenario, he adds. If the Type 2 PIP kinases are inhibited, and if p53 is deactivated, the cancer cell essentially "goes to sleep," he says. "It just stops dividing and growing. This is called synthetic lethality: You can get by without one gene or another, but if you lose both of them nothing can grow."


Shutting down these enzymes, as the researchers did in their experiments, puts cancer cells to sleep but has no effect on healthy cells. "A normal cell doesn't need Type 2 PIP kinases at all, so inhibitors of these enzymes should not be toxic to humans," Dr. Cantley says.


Because it is not possible to replace p53 proteins or the gene in cells that have lost it (many attempts have been made), deactivating Type 2 PIP kinases is the next-best thing, he adds. "This would likely be a very powerful advance in the treatment of many cancers."


###


This work was supported by NIH grant R01 GM041890 and by a Stand Up to Cancer Dream Team Translational Research Grant, a Program of the Entertainment Industry Foundation (SU2C-AACR-DT0209).


Co-authors include first author Dr. Brooke M. Emerling, Gary Bellinger and Rayman Choo-Wing from Weill Cornell Medical College; Dr. George Poulogiannis, Kazumi S. Tsukazawa, Hye-Seok Shim, and Dr. Gina M. DeNicola from Harvard Medical School; Dr. Gerburg M. Wulf, Dr. John M. Asara, Xin Yuan, and Dr. Andrea Bullock from Beth Israel Deaconess Medical School; Dr. Jonathan B. Hurov from Agios Pharmaceuticals; Dr. Eric L. Bell from the Massachusetts Institute of Technology; Dr. Katja A. Lamia from The Scripps Research Institute; Dr. Lucia E. Rameh from Boston University School of Medicine; Dr. Atsuo T. Sasaki from the University of Cincinnati College of Medicine; Dr. Jiaxi Song, Dr. Victoria Brown, and Dr. Sabina Signoretti from Dr. Dana-Farber Cancer Institute.


Weill Cornell Medical College

Weill Cornell Medical College, Cornell University's medical school located in New York City, is committed to excellence in research, teaching, patient care and the advancement of the art and science of medicine, locally, nationally and globally. Physicians and scientists of Weill Cornell Medical College are engaged in cutting-edge research from bench to bedside, aimed at unlocking mysteries of the human body in health and sickness and toward developing new treatments and prevention strategies. In its commitment to global health and education, Weill Cornell has a strong presence in places such as Qatar, Tanzania, Haiti, Brazil, Austria and Turkey. Through the historic Weill Cornell Medical College in Qatar, the Medical College is the first in the U.S. to offer its M.D. degree overseas. Weill Cornell is the birthplace of many medical advances including the development of the Pap test for cervical cancer, the synthesis of penicillin, the first successful embryo-biopsy pregnancy and birth in the U.S., the first clinical trial of gene therapy for Parkinson's disease, and most recently, the world's first successful use of deep brain stimulation to treat a minimally conscious brain-injured patient. Weill Cornell Medical College is affiliated with NewYork-Presbyterian Hospital, where its faculty provides comprehensive patient care at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. The Medical College is also affiliated with Houston Methodist. For more information, visit weill.cornell.edu.



Office of External Affairs

Weill Cornell Medical College

tel: 646.317.7401

email: pr@med.cornell.edu

Follow WCMC on Twitter and Facebook



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-11/wcmc-hbf110713.php
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GE experimenting with '3D painting' to repair metal parts


GE experimenting with '3D painting' to repair metal metal parts


Everyone is already all over this whole 3D printing thing. But 3D painting? It's a much emptier field. GE is experimenting with such a technology called "cold spray" that slowly builds up layers of metal by spraying metal powder at extremely high velocities. Instead of recreating works of art, the process is used to repair worn metal components, adding years or potentially decades to their life span. Unlike 3D printing which is severely limited in the size of the objects it can create, 3D painting is only limited by the spread of its spray. That means it could potentially be used to create or repair large structures, and not just prototype scale models of them. In particular, the process is being looked at as a way to repair parts used in oil and gas drilling. It could even be done on the scene and, unlike welding, there's no heat involved -- so there's very little chance for a fire or explosion. (And who wouldn't like to make our gas and oil wells safer.) For a quick demo of the process, check out the video after the break.



Source: http://www.engadget.com/2013/11/07/ge-experimenting-with-3d-painting/?ncid=rss_truncated
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Obama says he's sorry Americans losing insurance

FILE - In this Oct. 30, 2013, file photo, President Barack Obama speaks at Boston's historic Faneuil Hall about the federal health care law. Obama says he's sorry Americans are losing health insurance plans he repeatedly said they could keep under his signature health care law. But the president stopped short of apologizing for making those promises in the first place. "I am sorry that they are finding themselves in this situation based on assurances they got from me," he said in an interview Thursday, Nov. 7 with NBC News. (AP Photo/Stephan Savoia, File)







FILE - In this Oct. 30, 2013, file photo, President Barack Obama speaks at Boston's historic Faneuil Hall about the federal health care law. Obama says he's sorry Americans are losing health insurance plans he repeatedly said they could keep under his signature health care law. But the president stopped short of apologizing for making those promises in the first place. "I am sorry that they are finding themselves in this situation based on assurances they got from me," he said in an interview Thursday, Nov. 7 with NBC News. (AP Photo/Stephan Savoia, File)







(AP) — President Barack Obama says he's sorry Americans are losing health insurance plans he repeatedly said they could keep under his signature health care law. But the president stopped short of apologizing for making those promises in the first place.

"I am sorry that they are finding themselves in this situation based on assurances they got from me," he said in an interview Thursday with NBC News.

He added: "We've got to work hard to make sure that they know we hear them, and we are going to do everything we can to deal with folks who find themselves in a tough position as a consequence of this."

The president's apology comes as the White House tries to combat a cascade of troubles surrounding the rollout of the health care law often referred to as "Obamacare." The healthcare.gov website that was supposed to be an easy portal for Americans to purchase insurance has been riddled by technical issues. And with at least 3.5 million Americans receiving cancellation notices from their insurance companies, there's new scrutiny aimed at the way the president tried to sell the law to the public in the first place.

Much of the focus is on the president's promise that Americans who liked their insurance coverage would be able to keep it. He repeated the line often, both as the bill was debated in Congress and after it was signed into law.

But the measure itself made that promise almost impossible to keep. It mandated that insurance coverage must meet certain standards and that policies that fell short could no longer be sold except through a grandfathering process, meaning some policies were always expected to disappear.

The White House says under those guidelines, fewer than 5 percent of Americans will have to change their coverage. But in a nation of more than 300 million people, 5 percent is about 15 million people.

Officials argue that those people being forced to change plans will end up with better coverage and that subsidies offered by the government will help offset any increased costs.

"We weren't as clear as we needed to be in terms of the changes that were taking place," Obama told NBC. "And I want to do everything we can to make sure that people are finding themselves in a good position, a better position than they were before this law happened."

The president's critics have accused him of misleading the public about changes that were coming under the law, which remains unpopular with many Americans and a target for congressional Republicans.

Obama dismissed that criticism, saying "I meant what I said" and insisting that his administration was operating in "good faith." He acknowledged that the administration "didn't do a good enough job in terms of how we crafted the law" but did not specify what changes might be made.

Sign-ups for the new health care marketplaces opened Oct. 1. People have six months to enroll before facing a penalty.

Some lawmakers — including Democrats — have called on the White House to delay the penalty or extend the enrollment period because of the website woes that have prevented many used from signing up. Obama said he remains confident that anyone who wants to buy insurance will be able to do so.

"Keep in mind that the open enrollment period, the period during which you can buy health insurance is available all the way until March 31," he said. "And we're only five weeks into it."

Associated PressSource: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-11-07-Obama-Health%20Overhaul/id-b04d8aa89e6842cc87fcb77ae9982d78
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Hangouts 2.0 now rolling out with SMS support

Hangouts

New version lets you use Google's IM app to send and receive texts

As promised at last week's Google+ event, the new version of Hangouts capable of sending and receiving text messages is now rolling out through Google Play. The update to brings things up to speed with the version of Hangouts on the Nexus 5, which is the default SMS app on that device. When you first load up the updated Hangouts you'll be presented with a fullscreen message asking if you want to enable SMS support — tap yes and your messages are imported into the app, and you'll receive future SMS notifications through Hangouts instead of your preloaded SMS app. Tap "Maybe later" and things will stay as they are.

For the most part, the texting experience through Hangouts 2.0 on any other device is the same as it is on the Nexus 5 — SMS conversations are shown in a list alongside your other, and you can choose whether you want to communicate over Hangouts or SMS when starting a new conversation. Want out? At any point you can go to Settings > SMS > Turn on SMS to enable or disable SMS in Hangouts.

The update also adds animated GIF support and a new location-sharing button, which you can tap to tell contacts where you are.

As usual the update is being rolled out gradually across the Android user base, so don't be surprised if you don't see it immediately. If you're updating today, be sure to hit the comments and let us know whether you're opting into SMS in Hangouts or not.


    






Source: http://feedproxy.google.com/~r/androidcentral/~3/LDvv8kiS33A/story01.htm
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Microsoft Office Web Apps takes great leap toward Office equality



What are the most striking features of the new version of Office Web Apps? The ones that aren't there.


It isn't the fact that the Save button has been nixed (shades of Google Docs!) or that multiple users can edit the same document in real time and not stomp all over each other's work. It's how little -- as opposed to how much -- variation there is between OWA and its desktop counterparts.


That small margin makes a big difference.


Better collaborative editing than the desktop
Tony Bradley at PCWorld covers in detail all the new goodies in OWA, which still consists only of Word, Excel, and PowerPoint. The biggest is simultaneous co-authoring: Many users can log into OWA, open the same document, and work on it simultaneously. Flags within the document tell you where each user is.


One particularly smart touch here is how Microsoft has set different levels of editing granularity for each document type. For Word, it's a paragraph; for Excel, it's a cell; for PowerPoint, it's a slide. They're good commonsense defaults, and in my conversation with Microsoft's people, they hinted at the possibility that it could be made even more fine-grained.


From a practical standpoint, it's unlikely two people will attempt to edit the same sentence at once. But if Microsoft can nudge the line of thinking a smidge further in that direction, it's a sign of how completely Web apps could be able to eclipse their desktop cousins. For one, the desktop versions of these apps don't have anything like the simultaneous-editing features found in OWA -- a case where the Web app actually sports a feature superior to the desktop app.


This brings up the first of two big questions about OWA. Do Web apps need to displace their desktop counterparts?


The answer may be different depending on whether you're asking Microsoft or end-users. End-users may enjoy the convenience of OWA, but there comes a point where OWA simply can't deliver. The longer and more complex the document, the greater the odds OWA -- or your browser -- will simply gag.


There's little question that Microsoft needs to create a product portfolio off the desktop that's as valuable and rich as the one the company has created on it. But I doubt it can move people off desktop editions of Office and into OWA anytime soon, and not just because OWA's feature set is lacking.


Source: http://www.infoworld.com/t/office-software/microsoft-office-web-apps-takes-great-leap-toward-office-equality-230424?source=rss_applications
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'There will be catastrophic damage'


One of the most powerful typhoons ever recorded slammed into the Philippines early Friday, and one weather expert warned, "There will be catastrophic damage."



The U.S. Navy's Joint Typhoon Warning Center shortly before Typhoon Haiyan's landfall said its maximum sustained winds were 314 kilometers per hour (195 mph), with gusts up to 379 kilometers per hour (235 mph).



"195-mile-per-hour winds, there aren't too many buildings constructed that can withstand that kind of wind," said Jeff Masters, a former hurricane meteorologist who is meteorology director at the private firm Weather Underground.



Masters said the storm had been poised to be the strongest tropical cyclone ever recorded at landfall. He warned of catastrophic damage.



Local authorities reported having troubles reaching colleagues in the landfall area.



The local weather bureau had a lower reading on the storm's power, saying its speed at landfall in Eastern Samar province's Guiuan township had sustained winds at 235 kilometers (147 miles) per hour, with gusts of 275 kph (170 mph). The bureau takes measures based on longer periods of time.



Authorities in Guiuan could not immediately be reached for word of any deaths or damage, regional civil defense chief Rey Gozon told DZBB radio. Forecaster Mario Palafox with the national weather bureau said it had lost contact with its staff in the landfall area.



The storm was not expected to directly hit the flood-prone capital, Manila, further north.



The National Disaster Risk Reduction and Management Council said more than 125,000 people had been evacuated from towns and villages in the typhoon's path.



Typhoon Haiyan's wind strength at landfall had been expected to beat out Hurricane Camille, which was 305 kilometers per hour (190 mph) at landfall in the United States 1969, Masters said.



The only tiny bright side is that it's a fast-moving storm, so flooding from heavy rain — which usually causes the most deaths from typhoons in the Philippines — may not be as bad, Masters said.



"The wind damage should be the most extreme in Phillipines history," he said.



The storm later will be a threat to both Vietnam and Laos and is likely to be among the top five natural disasters for those two countries, Masters said. The storm is forecast to barrel through the Philippines' central region Friday and Saturday before blowing toward the South China Sea over the weekend, heading toward Vietnam.



President Benigno Aquino III on Thursday warned people to leave high-risk areas, including 100 coastal communities where forecasters said the storm surge could reach up to 7 meters (23 feet). He urged seafarers to stay in port.



Aquino ordered officials to aim for zero casualties, a goal often not met in an archipelago lashed by about 20 tropical storms each year, most of them deadly and destructive. Haiyan is the 24th such storm to hit the Philippines this year.



The president also assured the public of war-like preparations: three C-130 air force cargo planes and 32 military helicopters and planes on standby, along with 20 navy ships.



"No typhoon can bring Filipinos to their knees if we'll be united," he said in a televised address.



———



Associated Press writers Oliver Teves and Teresa Cerojano in the Philippines and Seth Borenstein in Washington contributed to this report.




Source: http://abcnews.go.com/International/wireStory/thousands-flee-philippines-typhoon-nears-20812186
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